Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia.
Identifieur interne : 000249 ( Main/Exploration ); précédent : 000248; suivant : 000250Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia.
Auteurs : I. Martín-Loeches [Espagne] ; J F Bermejo-Martin ; J. Vallés ; R. Granada ; L. Vidaur ; J C Vergara-Serrano ; M. Martín ; J C Figueira ; J M Sirvent ; J. Blanquer ; D. Suarez ; A. Artigas ; A. Torres ; E. Diaz ; A. RodriguezSource :
- Intensive care medicine [ 1432-1238 ] ; 2013.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Co-infection (MeSH), Comorbidité (MeSH), Durée du séjour (MeSH), Espagne (épidémiologie), Femelle (MeSH), Grippe humaine (mortalité), Grippe humaine (thérapie), Grippe humaine (traitement médicamenteux), Humains (MeSH), Indice APACHE (MeSH), Insuffisance respiratoire (mortalité), Insuffisance respiratoire (traitement médicamenteux), Insuffisance respiratoire (étiologie), Macrolides (usage thérapeutique), Mortalité hospitalière (MeSH), Mâle (MeSH), Pneumopathie virale (mortalité), Pneumopathie virale (thérapie), Pneumopathie virale (traitement médicamenteux), Résultat thérapeutique (MeSH), Score de propension (MeSH), Sous-type H1N1 du virus de la grippe A (MeSH), Unités de soins intensifs (statistiques et données numériques), Études multicentriques comme sujet (MeSH), Études prospectives (MeSH).
- MESH :
- mortalité : Grippe humaine, Insuffisance respiratoire, Pneumopathie virale.
- statistiques et données numériques : Unités de soins intensifs.
- thérapie : Grippe humaine, Pneumopathie virale.
- traitement médicamenteux : Grippe humaine, Insuffisance respiratoire, Pneumopathie virale.
- usage thérapeutique : Macrolides.
- épidémiologie : Espagne.
- étiologie : Insuffisance respiratoire.
- Adulte, Adulte d'âge moyen, Co-infection, Comorbidité, Durée du séjour, Femelle, Humains, Indice APACHE, Mortalité hospitalière, Mâle, Résultat thérapeutique, Score de propension, Sous-type H1N1 du virus de la grippe A, Études multicentriques comme sujet, Études prospectives.
- Wicri :
- geographic : Espagne.
English descriptors
- KwdEn :
- APACHE (MeSH), Adult (MeSH), Coinfection (MeSH), Comorbidity (MeSH), Female (MeSH), Hospital Mortality (MeSH), Humans (MeSH), Influenza A Virus, H1N1 Subtype (MeSH), Influenza, Human (drug therapy), Influenza, Human (mortality), Influenza, Human (therapy), Intensive Care Units (statistics & numerical data), Length of Stay (MeSH), Macrolides (therapeutic use), Male (MeSH), Middle Aged (MeSH), Multicenter Studies as Topic (MeSH), Pneumonia, Viral (drug therapy), Pneumonia, Viral (mortality), Pneumonia, Viral (therapy), Propensity Score (MeSH), Prospective Studies (MeSH), Respiratory Insufficiency (drug therapy), Respiratory Insufficiency (etiology), Respiratory Insufficiency (mortality), Spain (epidemiology), Treatment Outcome (MeSH).
- MESH :
- chemical , therapeutic use : Macrolides.
- geographic , epidemiology : Spain.
- drug therapy : Influenza, Human, Pneumonia, Viral, Respiratory Insufficiency.
- etiology : Respiratory Insufficiency.
- mortality : Influenza, Human, Pneumonia, Viral, Respiratory Insufficiency.
- statistics & numerical data : Intensive Care Units.
- therapy : Influenza, Human, Pneumonia, Viral.
- APACHE, Adult, Coinfection, Comorbidity, Female, Hospital Mortality, Humans, Influenza A Virus, H1N1 Subtype, Length of Stay, Male, Middle Aged, Multicenter Studies as Topic, Propensity Score, Prospective Studies, Treatment Outcome.
Abstract
PURPOSE
To determine whether macrolide-based treatment is associated with mortality in critically ill H1N1 patients with primary viral pneumonia.
METHODS
Secondary analysis of a prospective, observational, multicenter study conducted across 148 Intensive Care Units (ICU) in Spain.
RESULTS
Primary viral pneumonia was present in 733 ICU patients with pandemic influenza A (H1N1) virus infection with severe respiratory failure. Macrolide-based treatment was administered to 190 (25.9 %) patients. Patients who received macrolides had chronic obstructive pulmonary disease more often, lower severity on admission (APACHE II score on ICU admission (13.1 ± 6.8 vs. 14.4 ± 7.4 points, p < 0.05), and multiple organ dysfunction syndrome less often (23.4 vs. 30.1 %, p < 0.05). Length of ICU stay in survivors was not significantly different in patients who received macrolides compared to patients who did not (10 (IQR 4-20) vs. 10 (IQR 5-20), p = 0.9). ICU mortality was 24.1 % (n = 177). Patients with macrolide-based treatment had lower ICU mortality in the univariate analysis (19.2 vs. 28.1 %, p = 0.02); however, a propensity score analysis showed no effect of macrolide-based treatment on ICU mortality (OR = 0.87; 95 % CI 0.55-1.37, p = 0.5). Moreover, the sensitivity analysis revealed very similar results (OR = 0.91; 95 % CI 0.58-1.44, p = 0.7). A separate analysis of patients under mechanical ventilation yielded similar results (OR = 0.77; 95 % CI 0.44-1.35, p = 0.4).
CONCLUSION
Our results suggest that macrolide-based treatment was not associated with improved survival in critically ill H1N1 patients with primary viral pneumonia.
DOI: 10.1007/s00134-013-2829-8
PubMed: 23344833
PubMed Central: PMC7094901
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>APACHE (MeSH)</term>
<term>Adult (MeSH)</term>
<term>Coinfection (MeSH)</term>
<term>Comorbidity (MeSH)</term>
<term>Female (MeSH)</term>
<term>Hospital Mortality (MeSH)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (MeSH)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (mortality)</term>
<term>Influenza, Human (therapy)</term>
<term>Intensive Care Units (statistics & numerical data)</term>
<term>Length of Stay (MeSH)</term>
<term>Macrolides (therapeutic use)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Multicenter Studies as Topic (MeSH)</term>
<term>Pneumonia, Viral (drug therapy)</term>
<term>Pneumonia, Viral (mortality)</term>
<term>Pneumonia, Viral (therapy)</term>
<term>Propensity Score (MeSH)</term>
<term>Prospective Studies (MeSH)</term>
<term>Respiratory Insufficiency (drug therapy)</term>
<term>Respiratory Insufficiency (etiology)</term>
<term>Respiratory Insufficiency (mortality)</term>
<term>Spain (epidemiology)</term>
<term>Treatment Outcome (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Co-infection (MeSH)</term>
<term>Comorbidité (MeSH)</term>
<term>Durée du séjour (MeSH)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Grippe humaine (mortalité)</term>
<term>Grippe humaine (thérapie)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Humains (MeSH)</term>
<term>Indice APACHE (MeSH)</term>
<term>Insuffisance respiratoire (mortalité)</term>
<term>Insuffisance respiratoire (traitement médicamenteux)</term>
<term>Insuffisance respiratoire (étiologie)</term>
<term>Macrolides (usage thérapeutique)</term>
<term>Mortalité hospitalière (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Pneumopathie virale (mortalité)</term>
<term>Pneumopathie virale (thérapie)</term>
<term>Pneumopathie virale (traitement médicamenteux)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Score de propension (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (MeSH)</term>
<term>Unités de soins intensifs (statistiques et données numériques)</term>
<term>Études multicentriques comme sujet (MeSH)</term>
<term>Études prospectives (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Macrolides</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>Spain</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Respiratory Insufficiency</term>
</keywords>
<keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
<term>Respiratory Insufficiency</term>
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<keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Grippe humaine</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
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<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Unités de soins intensifs</term>
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<keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Influenza, Human</term>
<term>Pneumonia, Viral</term>
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<keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Grippe humaine</term>
<term>Pneumopathie virale</term>
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<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Grippe humaine</term>
<term>Insuffisance respiratoire</term>
<term>Pneumopathie virale</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Macrolides</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Espagne</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Insuffisance respiratoire</term>
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<keywords scheme="MESH" xml:lang="en"><term>APACHE</term>
<term>Adult</term>
<term>Coinfection</term>
<term>Comorbidity</term>
<term>Female</term>
<term>Hospital Mortality</term>
<term>Humans</term>
<term>Influenza A Virus, H1N1 Subtype</term>
<term>Length of Stay</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Multicenter Studies as Topic</term>
<term>Propensity Score</term>
<term>Prospective Studies</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Co-infection</term>
<term>Comorbidité</term>
<term>Durée du séjour</term>
<term>Femelle</term>
<term>Humains</term>
<term>Indice APACHE</term>
<term>Mortalité hospitalière</term>
<term>Mâle</term>
<term>Résultat thérapeutique</term>
<term>Score de propension</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Études multicentriques comme sujet</term>
<term>Études prospectives</term>
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<front><div type="abstract" xml:lang="en"><p><b>PURPOSE</b>
</p>
<p>To determine whether macrolide-based treatment is associated with mortality in critically ill H1N1 patients with primary viral pneumonia.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>Secondary analysis of a prospective, observational, multicenter study conducted across 148 Intensive Care Units (ICU) in Spain.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>Primary viral pneumonia was present in 733 ICU patients with pandemic influenza A (H1N1) virus infection with severe respiratory failure. Macrolide-based treatment was administered to 190 (25.9 %) patients. Patients who received macrolides had chronic obstructive pulmonary disease more often, lower severity on admission (APACHE II score on ICU admission (13.1 ± 6.8 vs. 14.4 ± 7.4 points, p < 0.05), and multiple organ dysfunction syndrome less often (23.4 vs. 30.1 %, p < 0.05). Length of ICU stay in survivors was not significantly different in patients who received macrolides compared to patients who did not (10 (IQR 4-20) vs. 10 (IQR 5-20), p = 0.9). ICU mortality was 24.1 % (n = 177). Patients with macrolide-based treatment had lower ICU mortality in the univariate analysis (19.2 vs. 28.1 %, p = 0.02); however, a propensity score analysis showed no effect of macrolide-based treatment on ICU mortality (OR = 0.87; 95 % CI 0.55-1.37, p = 0.5). Moreover, the sensitivity analysis revealed very similar results (OR = 0.91; 95 % CI 0.58-1.44, p = 0.7). A separate analysis of patients under mechanical ventilation yielded similar results (OR = 0.77; 95 % CI 0.44-1.35, p = 0.4).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Our results suggest that macrolide-based treatment was not associated with improved survival in critically ill H1N1 patients with primary viral pneumonia.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23344833</PMID>
<DateCompleted><Year>2013</Year>
<Month>09</Month>
<Day>26</Day>
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<DateRevised><Year>2020</Year>
<Month>03</Month>
<Day>27</Day>
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<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1238</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>39</Volume>
<Issue>4</Issue>
<PubDate><Year>2013</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Intensive care medicine</Title>
<ISOAbbreviation>Intensive Care Med</ISOAbbreviation>
</Journal>
<ArticleTitle>Macrolide-based regimens in absence of bacterial co-infection in critically ill H1N1 patients with primary viral pneumonia.</ArticleTitle>
<Pagination><MedlinePgn>693-702</MedlinePgn>
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<ELocationID EIdType="doi" ValidYN="Y">10.1007/s00134-013-2829-8</ELocationID>
<Abstract><AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To determine whether macrolide-based treatment is associated with mortality in critically ill H1N1 patients with primary viral pneumonia.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">Secondary analysis of a prospective, observational, multicenter study conducted across 148 Intensive Care Units (ICU) in Spain.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Primary viral pneumonia was present in 733 ICU patients with pandemic influenza A (H1N1) virus infection with severe respiratory failure. Macrolide-based treatment was administered to 190 (25.9 %) patients. Patients who received macrolides had chronic obstructive pulmonary disease more often, lower severity on admission (APACHE II score on ICU admission (13.1 ± 6.8 vs. 14.4 ± 7.4 points, p < 0.05), and multiple organ dysfunction syndrome less often (23.4 vs. 30.1 %, p < 0.05). Length of ICU stay in survivors was not significantly different in patients who received macrolides compared to patients who did not (10 (IQR 4-20) vs. 10 (IQR 5-20), p = 0.9). ICU mortality was 24.1 % (n = 177). Patients with macrolide-based treatment had lower ICU mortality in the univariate analysis (19.2 vs. 28.1 %, p = 0.02); however, a propensity score analysis showed no effect of macrolide-based treatment on ICU mortality (OR = 0.87; 95 % CI 0.55-1.37, p = 0.5). Moreover, the sensitivity analysis revealed very similar results (OR = 0.91; 95 % CI 0.58-1.44, p = 0.7). A separate analysis of patients under mechanical ventilation yielded similar results (OR = 0.77; 95 % CI 0.44-1.35, p = 0.4).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Our results suggest that macrolide-based treatment was not associated with improved survival in critically ill H1N1 patients with primary viral pneumonia.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Martín-Loeches</LastName>
<ForeName>I</ForeName>
<Initials>I</Initials>
<AffiliationInfo><Affiliation>Critical Care Center, ParcTaulí Hospital-Sabadell, CIBERes, ParcTauli s/n, 08208, Sabadell, Spain. drmartinloeches@gmail.com</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Bermejo-Martin</LastName>
<ForeName>J F</ForeName>
<Initials>JF</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vallés</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Granada</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vidaur</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Vergara-Serrano</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Martín</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Figueira</LastName>
<ForeName>J C</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Sirvent</LastName>
<ForeName>J M</ForeName>
<Initials>JM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Blanquer</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Author>
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</ArticleIdList>
<ReferenceList><Reference><Citation>Chest. 2003 May;123(5):1503-11</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12740267</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Bronconeumol. 2005 May;41(5):272-89</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15919009</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care. 2007;11(2):R31</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17331245</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Curr Infect Dis Rep. 2007 Jan;9(1):7-13</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17254499</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care Med. 2003 Apr;31(4):1250-6</Citation>
<ArticleIdList><ArticleId IdType="pubmed">12682500</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Intern Med. 1999 Nov 22;159(21):2562-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">10573046</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2010 Mar 15;50(6):850-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20136415</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Arch Intern Med. 2001 Aug 13-27;161(15):1837-42</Citation>
<ArticleIdList><ArticleId IdType="pubmed">11493124</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2011 Mar;139(3):555-562</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20930007</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 1998 Mar;157(3 Pt 1):853-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">9517602</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Respir Med. 1991 Jul;85(4):313-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">1947369</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Intensive Care Med. 2010 Apr;36(4):612-20</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19953222</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2009 Nov 4;302(17 ):1872-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19822627</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Antimicrob Chemother. 2009 May;63(5):1025-33</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19293196</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Transplant. 2007 Jan;7(1):76-82</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17061983</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Aug 13;361(7):680-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19564631</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Antimicrob Chemother. 2011 May;66(5):1150-5</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21393197</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17278083</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care. 2005 Dec 06;10(1):R8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16420641</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect Dev Ctries. 2009 Apr 30;3(3):159-61</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19759469</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2007 Feb;131(2):466-73</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17296649</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2004 Aug 15;170(4):440-4</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15184200</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2009 Nov 12;361(20):1925-34</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19815860</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Semin Respir Crit Care Med. 2012 Jun;33(3):311-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">22718217</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Respir Crit Care Med. 2011 May 1;183(9):1207-14</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21471084</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Infect. 2011 Mar;62(3):193-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21295604</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Am J Med. 2004 Nov 8;117 Suppl 9A:5S-11S</Citation>
<ArticleIdList><ArticleId IdType="pubmed">15586558</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care. 2009;13(6):R201</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20003352</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care. 2009;13(5):R148</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19747383</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Chest. 2011 Feb;139(2):382-386</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20688928</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2009 Jan;33(1):153-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">18768577</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Intensive Care Med. 2011 Feb;37(2):272-83</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21107529</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>J Antimicrob Chemother. 2011 May;66(5):1140-9</Citation>
<ArticleIdList><ArticleId IdType="pubmed">21385717</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Crit Care Med. 2007 Jun;35(6):1493-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17452932</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Eur Respir J. 2007 Jan;29(1):91-7</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17050564</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>N Engl J Med. 2010 May 6;362(18):1708-19</Citation>
<ArticleIdList><ArticleId IdType="pubmed">20445182</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>JAMA. 2009 Nov 4;302(17):1896-902</Citation>
<ArticleIdList><ArticleId IdType="pubmed">19887665</ArticleId>
</ArticleIdList>
</Reference>
</ReferenceList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Espagne</li>
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<name sortKey="Diaz, E" sort="Diaz, E" uniqKey="Diaz E" first="E" last="Diaz">E. Diaz</name>
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<name sortKey="Sirvent, J M" sort="Sirvent, J M" uniqKey="Sirvent J" first="J M" last="Sirvent">J M Sirvent</name>
<name sortKey="Suarez, D" sort="Suarez, D" uniqKey="Suarez D" first="D" last="Suarez">D. Suarez</name>
<name sortKey="Torres, A" sort="Torres, A" uniqKey="Torres A" first="A" last="Torres">A. Torres</name>
<name sortKey="Valles, J" sort="Valles, J" uniqKey="Valles J" first="J" last="Vallés">J. Vallés</name>
<name sortKey="Vergara Serrano, J C" sort="Vergara Serrano, J C" uniqKey="Vergara Serrano J" first="J C" last="Vergara-Serrano">J C Vergara-Serrano</name>
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